非小细胞肺癌的生物标志物测试实践:来自韩国病理学实验室的调查见解
Sehui Kim1,2, Dajeong Kim1, Lucia Kim3
1Department of Pathology, Korea University School of Medicine, Seoul, Korea.
Cancer research and treatment
|January 30, 2026
概括
针对非小细胞肺癌的分子生物标志物测试在韩国很普遍,下一代测序 (NGS) 的使用越来越多. 需要进一步的改革来规范实践,提高精确瘤护理.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 基因组学就是基因组学.
背景情况:
- 分子生物标志物测试对于非小细胞肺癌 (NSCLC) 的个性化治疗至关重要.
- 了解当前的测试实践对于优化精准医学策略至关重要.
研究的目的:
- 评估韩国病理学实验室中NSCLC目前的分子生物标记测试实践.
- 评估各种测试平台的采用情况,包括下一代测序 (NGS).
主要方法:
- 在韩国的30个病理学实验室中进行了一项全国性调查.
- 收集的数据包括测试政策,样本类型,生物标志物目标,平台实施 (NGS),报告,周转时间 (TATs) 和挑战.
主要成果:
- 生物标志物测试是经常进行的,反射测试的使用率为66.7%.
- EGFR,ALK,ROS1和PD-L1在非状NSCLC中被普遍测试;NGS被广泛采用用于组织,并越来越多地用于液体活检.
- 根据方法,TAT的中位数有很大的差异,其中包括样本可用性和标准化等挑战.
结论:
- 对NSCLC的分子生物标志物测试在韩国已经很成熟,NGS的整合越来越多.
- 虽然实践与国际准则保持一致,但需要进行系统和政策改革,以协调工作流程并提高精确瘤学.
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