青少年和年轻成年人肥胖药物开放的差异:回顾性链接的EHR-药房队列,2020-2025年
Isa Granados1, Kristen Wolfgang2,3, Kamyar Arasteh4
1Center for Healthcare Delivery Science, Nemours Children's Health, Jacksonville, Florida, USA.
Obesity (Silver Spring, Md.)
|January 30, 2026
概括
近一半的青少年和年轻成年人肥胖药物处方从未被填写,这突出了西班牙裔年轻人的持续进入障碍和不平等. 解决保险和处方覆盖面对改善公平获得这些治疗的机会至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 肥胖是青少年和年轻成年人 (AYA) 的日益严重的公共卫生问题.
- 肥胖药物 (OMs) 为AYA提供了潜在的治疗途径.
- 在AYA中对OM处方和发放的真实数据有限.
研究的目的:
- 描述现实世界肥胖药物 (OM) 处方和发行模式在AYA.
- 为了确定与这种人群中OMs的分发相关的因素.
- 检查OM访问中的潜在不平等现象.
主要方法:
- 追溯队列研究将电子健康记录 (EHR) 与发行数据 (2020-2025) 联系起来.
- 包括年龄在12-20岁的AYA处方特定的OM (利拉格卢提德,塞马格卢提德,芬特明,芬特明-托皮拉玛,蒂尔泽帕提德),不包括糖尿病患者.
- 多级物流回归分析了基于人口统计,社会经济因素,保险和药物类型的发行几率.
主要成果:
- 在1194个有OM处方的AYA中,56.7%至少获得了一次补充.
- 分发几率因药物而异,利拉格卢提德,芬特明和芬特明-托皮拉胺的几率高于西马格卢提德.
- 西班牙裔AYA的发行率低于非西班牙裔白人同龄人. 公共和混合保险,以及处方保险,与更高的发行率有关. 尽管处方量增加,但处方率下降.
- 与非西班牙裔白人同龄人相比,西班牙裔AYA的发药几率较低 (OR 0.61;p ≤ 0.001).
结论:
- 对于AYA的OM处方中,很大一部分仍未被填写,这表明治疗启动存在重大障碍.
- 机会不平等不成比例地影响了西班牙裔年轻人.
- 改善保险和处方覆盖率对于提高AYA获得肥胖药物的公平准入至关重要.
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