肝硬化患者的毛细血管微血管功能:指甲折叠视频毛细血管学研究
Ioanna Papagiouvanni1, Marieta Theodorakopoulou2, Adonis A Protopapas3
1Fourth Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Greece (Ioanna Papagiouvanni, Theodoros Dimitroulas, Emmanouil Sinakos, Ioannis Goulis).
Annals of gastroenterology
|January 30, 2026
概括
与健康个体相比,肝硬化患者的外周毛细血管密度显著降低. 这种受损的微循环随着肝硬化严重程度的增加而恶化,Child-Pugh评分表明了这一点.
科学领域:
- 血管生物学 血管生物学
- 胃肠病学 胃肠病学
- 医疗成像医学成像
背景情况:
- 肝硬化涉及由于血管活性剂失衡导致的显著的循环失调.
- 虽然系统性和肝脏内血管系统得到了充分的研究,但对肝硬化症中的外周微循环和内皮功能仍然不太了解.
- 肝硬化中的外周微循环功能需要进一步研究.
研究的目的:
- 评估肝硬化患者的外周微循环功能.
- 评估毛细血管密度使用指甲折视频毛细血管镜在肝硬化患者和对照.
- 为了将微循环功能与肝硬化严重程度相关联 (Child-Pugh类).
主要方法:
- 招募了60名肝硬化患者和20名健康对照患者.
- 所有参与者都进行了指甲视频毛囊镜检查.
- 毛细血管密度在基线测量,在封闭后反应性高血压期间,并在静脉拥堵后测量.
主要成果:
- 与对照人群相比,肝硬化患者在基线,高血压期间和拥堵后表现出明显较低的毛细血管密度.
- 在所有测量阶段,毛细血管密度随着儿童-普格等级 (A,B,C) 的恶化而逐渐降低.
- 观察到毛细血管密度降低和肝硬化晚期之间存在显著的相关性.
结论:
- 通过毛细血管密度评估的外周微循环功能在肝硬化患者中显著受损.
- 儿童-普格阶段的恶化与更明显的外周微循环损伤有关.
- 这些发现强调了肝硬化严重程度对外周内皮质功能和微血管完整性的影响.
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