狗中原发性肝血肉瘤与血外皮质:临床过程和治疗结果
Myeong-Yeon Lee1, Jong-Hyun Moon1, Jinsu Mok1
1Neuro Animal Medical Center, Busan, Republic of Korea.
Case reports in veterinary medicine
|January 30, 2026
概括
一只狗的破裂性肝血管肉瘤导致了侵略性的转移. 治疗包括手术,化疗和向治疗,存活时间为201天,突出了管理这种癌症的挑战.
科学领域:
- 兽医瘤学 兽医瘤学
- 狗癌症研究 狗癌症研究
- 手术病理学手术病理学
背景情况:
- 主要肝脏质量可能会破裂,导致狗的血.
- 狗血肉瘤是一种具有转移倾向的侵袭性恶性瘤.
- 破裂的肝血管肉瘤是一个关键的外科手术和瘤挑战.
研究的目的:
- 报告一只狗发生破裂原发性肝血类肉瘤的病例.
- 详细介绍多式联络治疗方法和结果.
- 为了研究与治疗反应相关的受体氨酸激酶 (RTK) 表达.
主要方法:
- 经过手术的肝叶切除术后稳定为血脉.
- 组织病理学检查和CD31免疫标记用于诊断.
- 多种模式的全身治疗包括VAC,多克索鲁比辛和托塞拉尼布.
- 对于RTK表达的死后免疫组织化学 (EGFR,VEGFR,HER2,KIT,PDGFR).
主要成果:
- 血管肉瘤的诊断得到证实;在手术后发现了多种腹内转移.
- 治疗因中性衰竭和贫血而复杂,需要调整剂量.
- 诊断后的生存时间为201天.
- 观察到异质RTK表达,包括EGFR,VEGFR和HER2阳性.
结论:
- 破裂的肝血管肉瘤是具有快速转移的高度攻击性.
- 多式疗法需要仔细管理不良事件.
- RTK表达可能会影响犬血类肉瘤的治疗策略.
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