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一个新的纠正的离子间隙将代谢酸攻击与胃潰瘍疾病联系起来
Xian-Ping Lin1, Song-Xing Lin2
1School of Nursing, Putian University, Putian, Fujian, China.
Frontiers in nutrition
|January 30, 2026
概括
纠正的离子间隙 (AGcorr) 是胃潰瘍疾病 (PUD) 的重要危險因素. 这一发现表明代谢酸负载在PUD病变发生过程中起作用,而二碳酸盐可能提供保护.
科学领域:
- 胃肠病学 胃肠病学
- 腎臟病學 (nephrology) 是一種醫學.
- 酸平衡是指酸平衡的情况.
背景情况:
- 系统酸平衡在生理上与胃酸分泌有关,这是胃潰瘍疾病 (PUD) 的关键因素.
- 连接酸平衡和PUD风险的流行病学证据目前有限.
研究的目的:
- 调查反映代谢酸负荷的新型修正离子间隙 (AGcorr) 和反映性储备的碳酸盐 (HCO3-) 与PUD风险之间的关系.
- 评估AGcorr和其他离子间隙指标在预测PUD方面的表现.
主要方法:
- 64名PUD患者和541名正常肝脏和功能控制者的回顾性病例对照研究.
- 分析了四种模型:AGcorr,HCO3-,未经校正的离子间隙 (AG) 和蛋白校正的AG (ACAG),根据性别,年龄和调整.
- 包括后期权力和灵敏度分析,扩大对照组和病例对照匹配.
主要成果:
- AGcorr与PUD风险显著积极相关 (OR = 1.167,P = 0.045) 具有很高的统计能力 (89%).
- 灵敏度分析证实了AGcorr-PUD关联,即使使用扩展对照 (OR = 1.138,P = 0.012) 和匹配的对照 (P = 0.020).
- HCO3-与PUD呈负相关性 (OR = 0.894,P = 0.043) 但具有较低的统计能力 (65%). 未经校正和蛋白校正的AG显示了显著的相关性,但模型不合适.
结论:
- 在正常肝脏和功能的人中,AGcorr是PUD的独立风险因素,其表现优于其他AG指标.
- 代谢非挥发性酸荷载可能会导致PUD的病原性,而二碳酸盐可能会提供保护作用.
- 结果表明,PUD护理的潜在改善,保证在多种人群中进一步验证.
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