在患有双极性障碍的患者中,一种剂量依赖的拉莫素诱导的嗜食症的病例
1Department of Psychiatry, University of Erzincan Binali Yıldırım, Mengucek Gazi Education and Research Hospital, Erzincan, Türkiye.
Noro psikiyatri arsivi
|January 30, 2026
概括
阳,持续勃起,可能是拉莫特里金的罕见副作用. 这一案例突出了双相情感障碍患者的剂量依赖反应,强调了在拉莫特里金剂量调整期间的仔细监测.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 青春期勃起是一种与性刺激无关的长期勃起,具有潜在的有机或药物诱导的原因.
- 与其他精神药物药物相比,与情绪稳定剂诱导的嗜食症的报道很少.
- 本报告详细介绍了一例与拉莫特里金使用相关的青症病例.
研究的目的:
- 报告一个用lamotrigine治疗的患者的priapism病例.
- 为了研究拉莫特里金和priapism之间潜在的剂量依赖关系.
- 提高对这种罕见的不良影响的临床意识.
主要方法:
- 一个24岁的男性被诊断患有双相情感障碍的案例研究.
- 分析药物病史,包括拉莫特里金,塞特拉林和瑞斯佩里.
- 在拉莫特里金剂量增加和剂量减少后解决后,观察priapism发作的观察.
主要成果:
- 在拉莫特里金剂量从每天200毫克增加到每天300毫克后一周,患者出现了priapism.
- 在拉莫特里金剂量减少到250毫克/天后的第二天,priapism症状消失了.
- 这表明,在这个患者中,拉莫特里金和青症之间存在剂量依赖的关联.
结论:
- 拉莫特里金可以诱导青症,可能以剂量依赖的方式.
- 对服用拉莫特里金的患者来说,临床考虑青风险至关重要,特别是在剂量升级期间.
- 以前的报道将拉莫特里金与性功能障碍联系起来,支持此案的发现.
相关概念视频
Bipolar Disorder
742
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
742
Drug Dosing: Geriatric Patients
269
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
269
Drug Dosing: Obese Patients
263
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
263
Personality Disorders: Dependent and Obsessive-Compulsive
450
Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle...
Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle...
450
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
671
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
A study on guinea pigs examined the...
671
Intrinsically Disordered Proteins
19.4K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.4K


