针对慢性腰部疼痛的药理处方的基于模型的经济评估:为期3年的马科夫分析
Ye-Seul Lee1, Sujin Kim1, In-Hyuk Ha1
1Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea.
Frontiers in public health
|January 30, 2026
概括
药术 (PPT) 比物理治疗 (PT) 更具有成本效益,用于慢性腰部疼痛 (cLBP). 这项研究发现,PPT以更低的成本提供了更高的质量调整寿命年 (QALYs),证明了其作为非药物治疗的价值.
科学领域:
- 卫生经济学 卫生经济学
- 疼痛管理 疼痛管理
- 传统医学 融合 传统医学 整合
背景情况:
- 慢性腰痛 (cLBP) 是全球残疾和医疗保健支出的主要原因之一.
- 目前对cLBP的药物治疗有局限性,需要有效的非药物替代品.
- 药术 (PPT) 在亚洲国家使用,但与标准物理治疗 (PT) 相比,缺乏国际成本效益数据.
研究的目的:
- 在慢性腰部疼痛 (cLBP) 患者中,与标准物理治疗 (PT) 相比,评估药术 (PPT) 的成本效益.
- 采用坚持国际药物经济指南的马尔科夫模型,以进行可靠的成本效益分析.
主要方法:
- 一个3状态 (轻度,中度,严重疼痛) 马尔科夫模型预测了3个月周期的3年结果.
- 来自实用RCT的临床数据为模型提供了信息,包括医疗保健成本,有限的社会和全面的社会视角.
- 用EQ-5D-5L计算质量调整寿命年 (QALY),并通过敏感性分析测试结果的稳定性.
主要成果:
- 在3年的时间里,PPT的成本低于PT,并且比PT更有效,从医疗保健和社会角度来看,PPT占据了PT的主导地位.
- PPT导致成本降低和QALY提高,在韩国支付意愿值时具有高成本效益的可能性.
- 敏感性分析证实了PPT在各种场景中的成本效益的稳定性.
结论:
- 这种基于模型的经济评估是cLBP中PPT的第一个,表明它在较低的成本下提供了比PT更高的QALY.
- PPT为cLBP管理提供了一种高价值的非药物替代方案.
- 研究结果支持将PPT纳入卫生系统,与世卫组织的优先事项保持一致,并为可持续的疼痛管理策略提供信息.
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