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Updated: Jan 31, 2026

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儿科鼻腔微生物组及其在慢性耳鼻腔疾病中的作用:叙述性综述
Adriana Elena Sîrbu1,2, Gratiela Gradisteanu Pircalabioru3,4,5, Diana Maria Deaconu3
1Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Frontiers in immunology
|January 30, 2026
概括
儿童鼻腔微生物组在健康儿童和患有慢性耳鼻喉 (ENT) 疾病的儿童之间有所不同. 了解这些微生物模式可以帮助早期疾病风险分层和有针对性的干预措施.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 人类微生物群,特别是鼻腔微生物群,对于免疫发育和生命早期对疾病的易感性至关重要.
- 儿科鼻腔微生物组在耳鼻喉 (ENT) 疾病中的作用尚不清楚.
- 慢性儿科耳鼻喉问题包括中耳炎,过敏性鼻炎,慢性鼻炎和腺体/桃体缩.
研究的目的:
- 审查和综合有关健康儿童与患有慢性儿科耳鼻病症儿童鼻腔微生物模式的现有证据.
- 为了比较与特定的儿科耳鼻病理相关的鼻菌群组成.
- 确定影响鼻腔微生物群的因素,并讨论未来临床应用的方向.
主要方法:
- 一个叙述的评论同行评审的文章发表在过去十年.
- 在Web of Science,PubMed,Google Scholar和CrossRef数据库中进行文献搜索.
- 综合发现,比较健康儿童和患有慢性耳鼻腔疾病的儿童的鼻子微生物群.
主要成果:
- 健康儿童的鼻子微生物群主要由保护性共生体,如Dolosigranulum和Corynebacterium主导.
- 患有慢性耳鼻喉疾病的儿童表现出微生物多样性减少和病原体增加 (* 血*, * 菌根杆菌*, * 菌根杆菌*).
- 环境,分娩方式,食和抗生素等因素显著调节鼻腔微生物群.
结论:
- 在健康和患病的儿科人群之间存在鼻腔微生物模式的显著差异.
- 鼻腔微生物组显示出预测和调节儿科耳鼻疾病的潜力.
- 挑战包括方法变化和有限的儿科特异性数据,需要进一步研究临床整合.
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