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自主小纤维参与痛苦的长期COVID:一个组织学和临床研究
Pietro Falco1, Eleonora Galosi1, Daniel Litewczuk1
1Department of Human Neuroscience, Sapienza University, Rome, Italy.
Frontiers in human neuroscience
|January 30, 2026
概括
自主小纤维损伤在痛苦的长期COVID综合征中是显而易见的,影响皮洛起器肌肉和汗腺. 即使其他神经纤维保持完好,神经损伤也会发生,这突显了这种神经疾病的关键特征.
科学领域:
- 神经学 神经学
- 病理学 病理学 病理学
- 自主神经科学 自主神经科学
背景情况:
- 长期COVID综合征越来越多地被认为是一种慢性神经疾病.
- 疼痛和自主症状是痛苦的长期COVID的标志.
- 自主小纤维参与长期COVID的作用需要进一步描述.
研究的目的:
- 在患有痛苦的长期COVID综合征的患者中调查自主小纤维参与.
- 为了分析皮肤活检数据,特别是神经纤维密度在肌肉导体肌肉 (PMNFD) 和汗腺 (SGNFD).
- 为了确定自主损伤是否独立于体质神经纤维损失.
主要方法:
- 从50名患有痛苦长期COVID综合征的患者的皮肤活检样本的回顾性分析.
- 患者和42名年龄和性别匹配的健康对照之间的PMNFD和SGNFD的比较.
- 在正常皮内神经纤维密度 (IENFD) 的患者中进行亚组分析,并与自主症状的COMPASS-31分数相关.
主要成果:
- 与对照组相比,在长期COVID患者中观察到PMNFD和SGNFD的显著减少 (p=0.0135;p<0.0001).
- 这些减少在正常IENFD的子组中持续存在 (p=0.0003; p=0.0005).
- 在PMNFD/SGNFD和COMPASS-31分数或疾病特征之间没有发现显著的相关性.
结论:
- 组织学证据证实,在痛苦的长期COVID综合征中,显著的自主小纤维损伤.
- 自主小纤维病理是可测量的,甚至存在于保存的体质神经纤维 (IENFD).
- 这表明自主功能障碍可能是长期COVID的独立特征,与体质神经损失不同.
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