重新思考ADHD作为神经肠道综合征:一个肠-大脑-寄生虫假设
Alexis Demas1,2
1Neurology Unit, Department of Neurology, Le Havre Hospital, Le Havre, France.
Frontiers in neuroscience
|January 30, 2026
概括
注意缺陷/多动障碍 (ADHD) 的一个子集可能是神经肠道综合征. 这一理论将肠道微生物群,寄生虫和免疫与神经分歧联系起来,表明现代环境中的进化不匹配.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 注意缺陷/多动障碍 (ADHD) 通常被视为一种基于大脑的疾病.
- 新出现的证据强调了肠-大脑轴和肠道免疫在认知和行为中的作用.
研究的目的:
- 提出一个神经肠道综合征框架,用于ADHD的子集和相关的神经分离型.
- 在塑造神经发育方面探索肠道微生物群,寄生虫和宿主免疫之间的共同进化相互作用.
主要方法:
- 综合来自ADHD,自闭症谱状况和偏头痛研究的数据.
- 在神经分化个体中审查改变微生物群,增加肠道透性和低度炎症的证据.
- 讨论对托芬代谢,阴道信号传递和大脑网络的潜在影响.
主要成果:
- 改变肠道微生物群,增加肠道透性和炎症在神经分化个体中被观察到.
- 这些肠道变化可能会影响涉及注意力和行为的神经通路.
- 一个进化假设表明,历史上的虫暴露形成了现在在ADHD中看到的特征.
结论:
- 一些ADHD表型可能代表进化肠道免疫系统和现代环境之间的不匹配综合征.
- 这种观点支持现有的ADHD治疗方法,并建议新的微生物,屏障和阴道干预措施.
- 对肠-大脑轴的进一步研究对于理解和管理神经发育状况至关重要.
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