维多利祖马布诱导的急性间歇性炎
Darren Fernandes1, Alok Mathew1, Alastair Ferraro2
1The Department of Gastroenterology, Nottingham Digestive Diseases Centre, Derby Road, Nottingham, NG7 2UH, United Kingdom.
Oxford medical case reports
|January 30, 2026
概括
用于性结肠炎 (UC) 的维多利祖马布很少会导致急性间歇性炎. 停止维多利祖马布和类固醇治疗导致UC患者的功能恢复.
科学领域:
- 胃肠道学和脏学
- 免疫学和药理学
背景情况:
- 维多利祖马布是一种肠道选择性抗因特林单克隆抗体,在性结肠炎 (UC) 中具有成熟的安全性.
- 与vedolizumab治疗相关的不寻常并发症需要胃肠科医生仔细监测和意识.
研究的目的:
- 报告一种罕见的急性间歇性炎 (AIN) 病例,该病例与UC患者的vedolizumab治疗有关.
- 强调在接受vedolizumab的患者中识别并发症的重要性.
主要方法:
- 一份病例报告详细介绍了患有UC和肝硬化症的53岁男性患者的临床表现,诊断工作和治疗.
- 包括诊断发现,如脏活检结果和治疗反应.
主要成果:
- 患者在UC的vedolizumab治疗期间,患有反应性尿沉积物导致功能恶化.
- 脏活检证实了急性间歇性炎.
- 停止使用维多利祖马布并开始高剂量类固醇治疗,导致功能显著恢复.
结论:
- 急性间歇性炎是一种潜在的,尽管很少见的,与UC患者的vedolizumab治疗相关的不良事件.
- 及时识别和管理,包括药物戒断和皮质类固醇治疗,可以带来有利的结局.
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