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YTHDF2的O-GlcNAcylation对抗ERK-依赖的酸化,并抑制肺癌

Jie Li1, Wen Zhou2, Jianzhi Zhang3

  • 1Beijing Key Laboratory of DNA Damage Response and College of Life Sciences, Capital Normal University, Beijing 100048, China.

Fundamental research
|January 30, 2026
PubMed
概括

在Thr-49中对YTHDF2的O相关的N-乙糖胺 (O-GlcNAc) 糖化对抗ERK酸化,促进其降解. 这种O-GlcNAcylation通过调高YTHDF2信号传输和调低c-Myc的影响影响肺癌的进展.

关键词:
细胞外信号调节的激酶.肺癌:肺癌是肺癌,而肺癌是肺癌.与O相关的N-乙葡萄糖胺.在RNAN6-甲基氨酸中.c-Myccc 的意思是我的

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