冷与新鲜胚胎转移对围产期的结果有影响吗?子宫内膜制备方法是否重要?
Haowen Zou1, Deirdre Zander-Fox2,3,4, Nicole Au1
1Department of Obstetrics and Gynaecology, Monash University, Melbourne, Victoria, Australia.
Human reproduction open
|January 30, 2026
概括
与新鲜移植相比,冷胚胎移植与较少的早产和低出生体重婴儿有关. 然而,它们与剖腹产率的增加,高出生体重和对于妊娠年龄的婴儿来说大的婴儿有关.
科学领域:
- 生殖医学 生殖医学
- 围产期流行病学 围产期流行病学
- 在体外受精 (IVF)
背景情况:
- 冷胚胎移植 (FET) 在试管婴儿中越来越多地使用,但其围产期风险仍在争论中.
- 以前的研究往往没有考虑到患者的特征或子宫内膜制备方法.
- 现有的出生体重图表可能低估了子宫内生长限制.
研究的目的:
- 调查冷和新鲜胚胎移植之间围产期结果的差异.
- 确定子宫内膜制备方法是否会影响这些结果.
主要方法:
- 多中心回顾性队列研究,8081名接受试管婴儿的妇女.
- 我们比较了来自冷 (6125) 和新鲜 (3118) 转移周期的9243个单独活产.
- 使用多变量波桑回归和概括估计方程 (GEE) 来分析结果,调整混因素.
主要成果:
- 冷转移显示早产率较低,出生体重较低,对于妊娠年龄来说小.
- 冷移植与剖腹产率更高,出生体重高,妊娠年龄大有关.
- 这些差异持续不论子宫内膜制备方法 (激素替代或自然循环).
结论:
- 由于子宫内膜制备方法,FET和新鲜移植之间的围产期结果差异不太可能存在.
- 潜在的因素包括新生周期或胚胎冷保存/加热过程中的子宫内膜受体受损.
- 需要进一步的研究来阐明潜在的机制.
相关概念视频
Classifying Matter by State
103.2K
Chemistry is the study of matter and the changes it undergoes. Matter is anything that has mass and occupies space. Matter is all around us; the air, water, soil, mountains, even our bodies are all examples of matter. Matter is divided into three states — solid, liquid, and gas — that are commonly found on earth. The fourth state of matter, plasma, occurs naturally in the interiors of stars.
103.2K
Classifying Matter by Composition
90.3K
Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
90.3K
Physical and Chemical Properties of Matter
166.3K
The characteristics that enable us to distinguish one substance from another are called properties.
166.3K
The Atomic Theory of Matter
127.9K
The earliest recorded discussion of the basic structure of matter comes from ancient Greek philosophers. Leucippus and Democritus argued that all matter was composed of small, finite particles that they called atomos, meaning “indivisible.” Later, Aristotle and others came to the conclusion that matter consisted of various combinations of the four “elements” — fire, earth, air, and water — and could be infinitely divided. Interestingly, these philosophers...
127.9K
What is Matter?
16.6K
The substance of the universe—from a grain of sand to a star—is called matter. Scientists define matter as anything that occupies space and has mass. An object’s mass and its weight are related concepts, but not quite the same. An object’s mass is the amount of matter contained in the object and is the same whether that object is on Earth or in the zero-gravity environment of outer space. An object’s weight, on the other hand, is its mass as affected by the pull of...
16.6K
States of Matter
2.9K
Solids, liquids, and gases are the three states of matter commonly found on Earth. A solid is rigid and possesses a definite shape. A liquid flows and takes the shape of its container, except it forms a flat or slightly curved upper surface when acted upon by gravity. Both liquid and solid samples have volumes nearly independent of pressure. A gas takes both the shape and volume of its container.
Scientists have discovered a fourth state of matter, plasma, that occurs naturally in the interiors...
Scientists have discovered a fourth state of matter, plasma, that occurs naturally in the interiors...
2.9K


