老年大脑中的:是时候重新思考叙述了
Ifrah Zawar1, Christos Panagiotis Lisgaras2,3, Arjune Sen4,5
1Epilepsy Division, Department of Neurology, School of Medicine, University of Virginia, Charlottesville, VA, USA.
Epilepsy currents
|January 30, 2026
概括
在老年人中,晚发性 (LOE) 需要从以为重点的护理转向大脑健康模型. 整合多模式生物标志物和多学科方法对于管理这种不断增长的人口至关重要.
科学领域:
- 神经学 神经学
- 老年病的医生 老年病的医生
- 生物标志物研究 生物标志物研究
背景情况:
- 老年人的是全球人口增长最快的部分.
- 晚发性 (LOE) 护理往往以为中心,忽视了诸如痴呆,死亡率和中风等更广泛的后果.
- 患有LOE的老年人在和阿尔茨海默病 (AD) 的临床试验中代表性不足.
研究的目的:
- 倡导多式联络生物标志物和对LOE的多学科护理.
- 将LOE重新定义为大脑脆弱性和病理学的警告信号,而不仅仅是并发症.
- 为老年人群管理提出一个全面的脑健康框架.
主要方法:
- 综述美国病学会2025年年会的主要主题和讨论,和衰老特别利益小组 (SIG) 会议.
- 分析LOE与认知功能障碍,神经成像,电生理学,心血管风险,睡眠障碍和AD生物学之间的交叉点.
- 提出一个以大脑健康为中心的框架,整合EEG,认知查,神经成像和生物标志物评估.
主要成果:
- 认知功能障碍是LOE中常见的早期临床信号,通常在神经退行性诊断之前.
- LOE与心血管因素,睡眠问题和AD病理学存在连续性,挑战了传统的护理孤岛.
- 当前的护理模式不足以解决以患者为中心的结果,如认知,睡眠,功能和生活质量.
结论:
- LOE需要转向以大脑健康为中心的模式.
- 多模式生物标志物,包括纵向EEG和认知查,对于有效的LOE管理至关重要.
- 增加老年人参与和AD临床试验对于推进研究和护理至关重要.
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