2型糖尿病和肥胖症患者的维生素D补充剂和选定的代谢参数:一项前性观察性研究
Karolina Hoffmann1, Wiesław Bryl1, Bhoomendra Bhongade2
1Department and Clinic of Internal Diseases and Metabolic Disorders, Poznan University of Medical Sciences, Poznań, Poland.
Frontiers in endocrinology
|January 30, 2026
概括
高剂量维生素D3补充剂改善了维生素D水平,并在患有2型糖尿病 (T2DM) 的肥胖患者中适度提高了血糖控制. 需要进一步的研究来证实这些在随机对照试验中的发现.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- 维生素D缺乏与2型糖尿病 (T2DM) 和肥胖中的代谢失调有关.
- 关于维生素D补充对T2DM患者的代谢影响的证据不一致.
研究的目的:
- 评估高剂量维生素D3对肥胖T2DM患者在甲胺单疗中的人类学和代谢参数的影响.
主要方法:
- 一项为期12周的前性队列研究,涉及200名T2DM患者.
- 干预组 (n=100) 每天服用4000 IU维生素D3;对照组 (n=100) 没有服用补充剂.
- 主要结局:血清25-基维生素D的变化[25(OH) D];次要结局:禁食血清葡萄糖 (FSG),HbA1c,血压 (BP),血清和体重指数 (BMI).
主要成果:
- 维生素D3补充剂显著增加了血清25(OH) D水平.
- 在干预组中观察到FSG和HbA1c的显著降低.
- 血压,血清或BMI没有显著变化. 较高的基线FSG,较长的糖尿病持续时间和较高的BMI预测了低于最佳的血糖反应.
结论:
- 高剂量的维生素D3补充剂改善了肥胖T2DM患者的维生素D状态和血糖控制.
- 该策略没有影响血压,水平或体重.
- 维生素D补充可能是糖尿病管理的辅助方法,需要通过随机对照试验进一步验证.
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