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梅托雷克萨特相关的淋巴增殖障碍,特征是T细胞表型与肺和关节参与:一个案例报告
Katsunori Arai1, Hirokazu Tokuyasu1, Yuriko Sueda1
1Respiratory Medicine Division, Matsue Red Cross Hospital, Matsue, Shimane, Japan, jrc.or.jp.
Case reports in medicine
|January 30, 2026
概括
甲托雷克萨特 (MTX) 可能导致罕见的T细胞淋巴增殖性疾病. 这种病例突显出一种极为罕见的MTX-LPD与外围T细胞淋巴瘤表型,显示肺和肌肉参与,在MTX停止后得到解决.
科学领域:
- 在瘤学瘤学.
- 类风湿病学 类风湿病学
- 病理学 病理学 病理学
背景情况:
- 甲基 (MTX) 是一种常见的药物,用于治疗类风湿性关节炎.
- MTX可以诱导MTX相关的淋巴增殖性疾病 (MTX-LPDs),通常具有T细胞表型.
- 涉及外围T细胞淋巴瘤 (PTCL) 现型的MTX-LPD异常罕见.
研究的目的:
- 报告一个极其罕见的MTX-LPD病例.
- 描述PTCL表型与异常的肺和骨肌肉参与.
- 强调在疑似MTX-LPD患者中考虑停止MTX的重要性.
主要方法:
- 一个66岁的风湿性关节炎男性患者长期接受MTX治疗的病例报告.
- 右关节疼痛的临床表现.
- 诊断成像 (CT扫描) 显示肺部和心肌肌肉质量.
- 瘤组织的病理和免疫组织化学检查.
主要成果:
- 患者在肺部和心肌肌肉中呈现出质量.
- 病理学证实了外围T细胞淋巴瘤 (PTCL) 现型.
- 停止MTX导致MTX-LPD的快速缓解.
结论:
- MTX-LPD可以呈现PTCL表型,并涉及肺部和骨肌肉等 extranodal网站.
- 早期识别和终止MTX对于管理MTX-LPD至关重要.
- 这一案例强调了MTX诱导的LPDs的多样化临床表现.
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