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肠道微生物群的组成与失眠严重程度相关:来自高通量测序分析的见解
Zhe Xu1, Jinxia Zhang1, Haifang Zhou2
1Sleep Medicine Center, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Frontiers in microbiology
|January 30, 2026
概括
失眠的严重程度与肠道微生物组的变化相关,包括较低的Firmicutes/Bacteroidetes比率和减少的Clostridia. 这些变化可能会影响肠-大脑轴的信号传输,可能会恶化睡眠质量.
科学领域:
- 微生物组研究的研究.
- 睡眠科学 睡眠科学
- 肠-大脑轴研究的研究.
背景情况:
- 失眠是一种普遍存在的睡眠障碍,对健康有重大影响.
- 肠道微生物组在宿主生理学中起着至关重要的作用,包括神经功能.
- 新出现的证据表明,肠道微生物群失调和睡眠障碍之间存在联系.
研究的目的:
- 为了研究肠道微生物群组成和多样性的差异性变化,在不同程度的失眠严重程度.
- 为阐明睡眠障碍与肠道微生物组之间的关系提供经验证据.
- 为了识别与失眠相关的特定微生物特征.
主要方法:
- 参与了120名失眠患者和20名健康对照人群.
- 在Illumina NovaSeq平台上使用16S rDNA高通量测序分析了肠道微生物群.
- 在轻度,中度和重度失眠组中评估了α和β多样性,以及物种组成.
主要成果:
- 与对照组相比,失眠患者的α多样性指数 (Chao1,ACE) 在失眠患者中升高.
- 贝塔多样性分析显示微生物社区结构的显著差异与失眠严重程度相关.
- 观察到Firmicutes/Bacteroidetes比率和Clostridia丰度的逐渐下降,失眠的严重程度增加.
结论:
- 肠道微生物群结构与失眠严重程度密切相关.
- 减少的Firmicutes/Bacteroidetes比率和减少的Clostridia丰度是失眠的特征.
- 这些微生物转移可能会通过肠-大脑轴损害神经免疫调节,可能会加剧睡眠失调.
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