碳纳米管诱导的酶聚合用于可穿戴的多功能生物传感器在汗水分析
Chun Bi1, Wen Fei2, Haoquan Zhang2
1Department of Orthopedics Trauma, Trauma Center, Shanghai General Hospital, Shanghai 201620, PR China.
JACS Au
|January 30, 2026
概括
这项研究介绍了一种用于检测尿酸和葡萄糖的新型可穿戴汗液传感器. 先进的电化学生物传感器提供超低的检测极限,以改善非侵入性健康监测.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 分析化学 分析化学
背景情况:
- 可穿戴的汗水传感器提供非侵入性健康监测,但面临着低分析剂度和检测极限的挑战.
- 现有的传感器在复杂的汗水环境中难以准确量化生物标志物.
研究的目的:
- 开发一种高灵敏度的电化学生物传感器,用于检测汗液中的尿酸和葡萄糖.
- 将包括pH监测在内的多功能传感功能集成到一个可穿戴平台中.
- 通过碳纳米管 (CNT) 诱导的酶聚合和先进的微流体学来提高传感器性能.
主要方法:
- 使用EDC/NHS对共价酶不动化的CNTs的功能化.
- 通过有限元分析优化的一种半径对称的微流体模块的开发.
- 整合基于pH值的信号校正,以提高实时汗水分析的准确性.
主要成果:
- 通过使用CNT诱导的酶聚合,达到尿酸和葡萄糖的超低检测极限.
- 证明了增强的催化效率,电子转移和传感器稳定性.
- 通过在人体上的志愿者研究验证了可穿戴传感器的强度和可靠性.
结论:
- 开发的多功能可穿戴汗液传感器显示了个性化医疗保健应用的巨大潜力.
- 这项工作为设计先进的可穿戴生物传感器提供了一个框架,通过结合材料和设备创新.
- 克服低分析物检测方面的挑战对于推进下一代非侵入性健康监测至关重要.
相关概念视频
Enzymes
94.7K
Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
94.7K
Accessory Structures of the Skin: Sweat Glands
3.8K
Sweat glands or sudoriferous glands are one of the important accessory structures of the skin. They are small, coiled tubular structures located in the dermis, the middle layer of the skin. Sweat glands are responsible for producing and secreting sweat, a watery fluid that helps regulate body temperature and excrete waste products.
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...
3.8K
The Carbon Cycle
43.7K
Carbon is the basis of all organic matter on Earth, and is recycled through the ecosystem in two primary processes: one in which carbon is exchanged among living organisms, and one in which carbon is cycled over long periods of time through fossilized organic remains, weathering of rocks, and volcanic activity. Human activities, including increased agricultural practices and the burning of fossil fuels, has greatly affected the balance of the natural carbon cycle.
43.7K
Carbon Skeletons
115.0K
Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side...
115.0K
Enzyme Kinetics
104.0K
Enzymes speed up reactions by lowering the activation energy of the reactants. The speed at which the enzyme turns reactants into products is called the rate of reaction. Several factors impact the rate of reaction, including the number of available reactants. Enzyme kinetics is the study of how an enzyme changes the rate of a reaction.
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...
104.0K
Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)
3.2K
Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...
3.2K


