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Updated: Jan 31, 2026

Pharmacophore Modeling for Targets with Extensive Ligand Libraries: A Case Study on SARS-CoV-2 Mpro
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Published on: September 26, 2025

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基于结构的共价SARS-CoV-2主要蛋白酶抑制剂的设计,针对耐尼马特里尔维尔抗性E166突变物

Zhengjun Cai1, Navita Kohaal2, Kyriakos Georgiou3

  • 1Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.

JACS Au
|January 30, 2026
PubMed
概括

一种新的候选药物Jun13698有效地抑制了SARS-CoV-2的主要蛋白酶 (Mpro),包括耐药变种. 这一发展提供了一种对抗COVID-19耐药性的有希望的策略.

关键词:
在 E166V 中使用.这就是SARS-CoV-2病毒.这是一种抗病毒药物.药物耐药性 耐药性 药物耐药性主要蛋白质酶的主要蛋白质酶

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