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Updated: Jan 31, 2026

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
07:04

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

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针对细胞类型特定的表面免疫检查点蛋白PD-L1的细胞类型特定降解的PSMA向化马体

Yuqing Luo1,2, Xiaoxiao Gong3, Keren Peng3

  • 1Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou, Zhejiang 310058, China.

JACS Au
|January 30, 2026
PubMed
概括

我们开发了针对PSMA的嵌合体 (PATACs) 来降解前列腺癌细胞中的蛋白质. 一个代表的PATAC,A4,有效地降低了编程细胞死亡联体1 (PD-L1) 和增强了T细胞的杀死.

关键词:
在PD-L1中.在PSMA上,PSMA可以在PSMA上进行交易.分子动力学模拟,分子动力学模拟前列腺癌是细胞特异性的前列腺癌.有针对性的蛋白质降解降解.

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