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Updated: Apr 1, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
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一个"内向外"的策略使得14个步骤的Hispidospermidin总合成成为可能

Charis Amber1, Tenta Nakamura1, Matthew Amoako1

  • 1Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, United States.

JACS Au
|January 30, 2026
PubMed
概括

这项研究通过早期构建复杂性来提出一种新的,更短的hspidospermidin合成方法. "内外"策略快速构建核心的bicyclo[3.3.1]-nonane结构,大大减少了步数.

关键词:
在他的pidospermidin.内部外策略 内部外策略异构化的异构化复杂合成的复杂合成总合成总合成

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In the presence of an aqueous base and a halogen, primary amides can lose the carbonyl (as carbon dioxide) and undergo rearrangement to form primary amines. This reaction, called the Hofmann rearrangement, can produce primary amines (aryl and alkyl) in high yields without contamination by secondary and tertiary amines.
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