预防和治疗癌症中的天然产品:当前的挑战和未来的方向
Ruimiao Qian1, Jun Ge1, Ni Fan1
1College of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine Tianjin China.
MedComm
|January 30, 2026
概括
自然产品通过向瘤代谢和瘤微环境 (TME) 来提供多方面的癌症干预措施. 本综述综合了它们在临床阶段的应用,增强了精确瘤学策略.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 自然产品研究 自然产品研究
背景情况:
- 自然产品是预防,治疗和支持性护理癌症生物活性化合物的重要来源.
- 它们的机制包括直接的细胞毒性,代谢途径调节和影响瘤微环境 (TME).
研究的目的:
- 系统地审查天然产品在瘤学中的代谢重编程和免疫-瘤组件的同时向.
- 通过临床连续性来划分它们的治疗应用,并探索创新的输送策略.
主要方法:
- 文献综述侧重于天然产品,如黄类,类和类.
- 分析它们对代谢途径 (葡萄糖,脂质,谷氨酸) 和TME成分 (纤维细胞,ECM,免疫细胞) 的影响.
- 检查传递系统 (纳米载体,代码传递) 以提高生物可用性和协同作用的组合.
主要成果:
- 自然产品破坏核心代谢途径,并影响TME元素,包括与癌症相关的纤维细胞,细胞外基质和免疫细胞.
- 创新的输送策略提高了生物可用性,并使与传统疗法的协同组合成为可能.
结论:
- 自然产品在多式模式的癌症治疗中发挥着重要作用,影响新陈代谢和TME.
- 将机制性见解与传递策略的整合支持它们在以生物标志物驱动的精密瘤治疗方案中的使用.
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