Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.0K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.0K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

5.6K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.6K
Embryonic Stem Cells00:58

Embryonic Stem Cells

32.4K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.4K
Embryonic Stem Cells00:57

Embryonic Stem Cells

5.0K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
5.0K
Adult Stem Cells01:33

Adult Stem Cells

33.8K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.8K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

4.5K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
4.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Multiomics analysis identifies VPA-induced changes in neural progenitor cells, ventricular-like regions, and cellular microenvironment in dorsal forebrain organoids.

Molecular psychiatry·2026
Same author

Single-cell, clonal and spatial atlases of cranial placodes illuminate their specification and evolution.

bioRxiv : the preprint server for biology·2026
Same author

Developmental determinants of male bias in medulloblastoma.

bioRxiv : the preprint server for biology·2026
Same author

A Cre-mediated copy number variant compromises the reliability of a <i>LoxP-STOP-LoxP</i>-<i>PLAG1</i> driven brain tumor model.

Neuro-oncology advances·2026
Same author

The evolution of gene regulation in mammalian cerebellum development.

Science (New York, N.Y.)·2026
Same author

Enhanced mGluR1 function causes motor deficits and region-specific Purkinje cell dysfunction.

Brain : a journal of neurology·2026

相关实验视频

Updated: Jan 31, 2026

Scalable Generation of Mature Cerebellar Organoids from Human Pluripotent Stem Cells and Characterization by Immunostaining
10:40

Scalable Generation of Mature Cerebellar Organoids from Human Pluripotent Stem Cells and Characterization by Immunostaining

Published on: June 13, 2020

11.5K

从多能干细胞中产生小脑器官.

Esther B E Becker1,2, Simone Mayer3,4, Lena M Kutscher5

  • 1Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

Disease models & mechanisms
|January 30, 2026
PubMed
概括

大脑小管器官对于研究人类大脑发育和疾病非常有价值. 制定强有力的标准对于确保这些有前途的小脑有机体模型的可靠性和有用性至关重要.

关键词:
大脑小部分的大脑小部分发展发展发展 发展发展疾病模型的疾病模型.有机器人机器人机器人机器人质量控制 质量控制

更多相关视频

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells
09:54

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells

Published on: April 18, 2019

14.5K
Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells
09:46

Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells

Published on: January 20, 2023

8.1K

相关实验视频

Last Updated: Jan 31, 2026

Scalable Generation of Mature Cerebellar Organoids from Human Pluripotent Stem Cells and Characterization by Immunostaining
10:40

Scalable Generation of Mature Cerebellar Organoids from Human Pluripotent Stem Cells and Characterization by Immunostaining

Published on: June 13, 2020

11.5K
Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells
09:54

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells

Published on: April 18, 2019

14.5K
Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells
09:46

Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells

Published on: January 20, 2023

8.1K

科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 干细胞研究 干细胞研究

背景情况:

  • 小脑器官正在成为研究人类小脑发育和相关疾病的强大模型.
  • 这个领域的快速增长需要标准化的方法和透明的报告.

研究的目的:

  • 审查目前生产小麦类有机体的方法.
  • 概述小脑器官在研究中的多种应用.
  • 为这个发展中地区提出基本的质量控制标准和生物读数.

主要方法:

  • 对现有的小麦细胞有机体生成协议的文献综述.
  • 报告的应用和实验读数的分析.
  • 关于标准化建议的综合报告.

主要成果:

  • 关于各种小麦细胞有机体生成技术的总结.
  • 目前应用的概述,包括疾病建模和药物查.
  • 确定标准化的关键领域.

结论:

  • 大脑小器官对我们对人类小脑的理解有很大的潜力.
  • 实施共同的质量控制标准和报告实践将提高可复制性和实用性.
  • 标准化工作对于大脑小器官研究的持续进展和影响至关重要.