患有甲状腺瘤的患者的不良结局 - 一个区域范围的真实世界数据
Wang Chun Kwok1,2, James Chung Man Ho1,2, Isaac Sze Him Leung3
1Division of Respiratory Medicine, Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Cancer medicine
|January 30, 2026
概括
中瘤患者经常出现问题,包括急性损伤和慢性病进展. 像贝瓦西祖马布和基化疗等治疗与这些不良结局有关.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床研究 临床研究
背景情况:
- 间皮瘤管理的进步改善了生存率,但引入了与治疗相关的副作用,如毒性.
- 间皮瘤患者中不良结局的患病率和危险因素在很大程度上仍未确定.
研究的目的:
- 评估中瘤患者急性损伤 (AKI),进展和慢性病 (CKD) 上升阶段的患病率.
- 确定与这些不良结局相关的风险因素.
主要方法:
- 分析香港公共医院的全境电子健康记录 (2000-2022年).
- 包括222名间皮瘤患者.
- 评估AKI,进展 (eGFR下降>30毫升/分钟),CKD升级阶段以及相关风险因素.
主要成果:
- 5.1%的患者患有AKI;风险因素包括糖尿病,贝瓦齐祖马布和第三空间液体.
- 21.2%的人经历了CKD升级,与第三空间流体,化疗,免疫疗法,AKI和化疗强度有关.
- 14.0%的患者表现出性进展,其中炎和贝瓦西祖马布的使用作为预测因素.
结论:
- 在中瘤患者中,短期和长期的不良结局是常见的.
- 这些结果显示与特定的癌症治疗有很强的关联.
- 密切监测功能和仔细选择患者对于减轻毒性至关重要.
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