心脑轴:亚临床心血管变化和大脑健康
Parnian Habibi1, Lin Yee Chen2, Farzaneh A Sorond3
1Department of Radiology Mayo Clinic Rochester MN USA.
Journal of the American Heart Association
|January 30, 2026
概括
亚临床心脑轴功能障碍,即使没有疾病,也会影响大脑健康和认知功能. 早期检测和干预对于保持大脑健康和预防神经衰退至关重要.
科学领域:
- 神经科学是一个神经科学.
- 心血管科学 心血管科学
- 老年学是一门学科.
背景情况:
- 心脑轴整合了心血管功能的神经调节和心血管对大脑健康的影响.
- 亚临床心血管变化可能导致脑损伤和认知脆弱性,即使没有确诊的疾病.
研究的目的:
- 审查如何亚临床心脑轴功能障碍影响大脑结构和功能.
- 突出默默脑损伤和认知衰退的生物标志物.
- 概述早期检测和预防的机制和未来研究方向.
主要方法:
- 文献综述综合了关于心脑轴的当前知识.
- 讨论神经通路,荷尔蒙信号和生物标志物.
- 确定机械路径和研究缺口.
主要成果:
- 亚临床心脑轴功能障碍有助于神经系统衰退.
- 确定了沉默性脑损伤,认知衰退和痴呆症的生物标志物.
- 机械路径将心血管变化与不良的大脑结果联系起来.
结论:
- 亚临床心脑轴功能障碍是大脑健康的一个重要因素.
- 使用生物标志物的早期风险分层是至关重要的.
- 未来的研究应该专注于早期检测和预防策略,以保持大脑健康.
相关概念视频
Hypothalamic-Pituitary Axis
66.0K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
66.0K
Brain Waves
4.1K
Brain waves are electrical signals generated by the neurons in the brain, which are regularly monitored to measure mental activities. Brain waves and their frequency ranges can be measured using an electroencephalogram or EEG. There are four main types of brain waves, each with distinct characteristics:
4.1K
Organization of the Brain
2.7K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
2.7K
Brain Imaging
734
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
734
Perpendicular-Axis Theorem
4.6K
The perpendicular-axis theorem states that the moment of inertia of a planar object about an axis perpendicular to its plane is equal to the sum of the moments of inertia about two mutually perpendicular concurrent axes lying in the plane of the body.
Consider a circular disc of mass M and radius R lying along an x-y plane. The origin lies at the center of the disc, and the z-axis is perpendicular to the disc's plane. All three axes coincide at the disc's center. The moment of inertia of this...
Consider a circular disc of mass M and radius R lying along an x-y plane. The origin lies at the center of the disc, and the z-axis is perpendicular to the disc's plane. All three axes coincide at the disc's center. The moment of inertia of this...
4.6K
Parallel-axis Theorem
8.3K
The parallel-axis theorem provides a convenient and quick method of finding the moment of inertia of an object about an axis parallel to the axis passing through its center of mass. Consider a thin rod as an example. There is a striking similarity between the process of finding the moment of inertia of a thin rod about an axis through its middle, where the center of mass lies, and about an axis through its end using the conventional method. In the conventional method, the concept of linear mass...
8.3K


