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Updated: Jan 31, 2026

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium
11:00

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium

Published on: June 22, 2010

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DAPK2 调节PKM2 在氨酸45的酸化,以促进扰乱的流动诱导性动脉样硬化

Shuai Guo1,2, Long Xu1, Yixin Chen3

  • 1Department of Physiology, Guangdong Key Laboratory of Vascular Diseases, Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China (S.G., L.X., Y. Zhao, Y. Zhang, R.Y., Y.X.).

Circulation
|January 30, 2026
PubMed
概括

与死亡相关的蛋白质激酶2 (DAPK2) 通过酸化酸盐激酶M2 (PKM2) 驱动动动脉硬化,促进内皮炎症. 抑制这种DAPK2-PKM2相互作用为动脉样硬化提供了潜在的治疗策略.

关键词:
动脉样硬化 动脉样硬化与死亡相关的蛋白质激酶2相关的死亡.干扰了流动的干扰.细胞内皮细胞的内皮细胞.这是一种炎症炎症炎症炎症.酸盐激酶M2的 pyruvate 激酶 M2 的 pyruvate 激酶 M2 的 pyruvate 激酶

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