网络协同激活与儿童创伤性脑损伤后的执行功能有关
Katherine A Billetdeaux1, Florencia Ontiveros1, Haileigh F Galloway1
1Center for Biobehavioral Health, https://ror.org/003rfsp33Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Journal of the International Neuropsychological Society : JINS
|January 30, 2026
概括
儿童创伤性脑损伤破坏了关键大脑网络中的功能连接,影响了执行功能. 网络调节障碍与儿童日常执行行为较差有关.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 临床神经学 临床神经学
背景情况:
- 年轻人的创伤性脑损伤 (TBI) 可以导致持续的认知缺陷,特别是影响执行功能.
- 了解这些缺陷的神经支,特别是大脑网络连接的改变,对于开发有针对性的干预措施至关重要.
研究的目的:
- 调查TBI的年轻人中主要大脑网络 (默认模式,中央执行,背部注意力,突出) 之间的功能连接.
- 在这个人群中检查功能连接和执行功能的改变之间的关系.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 用于评估23名患有TBI (中度至重度和复杂至轻度) 的青少年和17名骨科损伤对照者的功能连接.
- 通过使用标准化措施来评估家长评级的执行功能.
主要成果:
- 在默认模式网络 (DMN) 和突出网络 (SN) 连接方面观察到显著的群体差异.
- 与对照组相比,患有TBI的年轻人表现出改变的网络之间的连接,负面关联减弱.
- 较差的家长级执行功能与DMN的背带皮和SN区域之间的负连接性较弱有关.
结论:
- 儿童TBI破坏了SN对DMN的正常下调,表明网络调节受损.
- 这些功能连接的破坏与儿童TBI后观察到的执行功能缺陷有关.
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