相关实验视频

Updated: Jan 31, 2026

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Published on: October 17, 2017

工程化巨细胞辅助阿托瓦斯塔丁纳米疗法用于逆转动脉样硬化中的泡细胞形成

Xiaoyu Liang^1,2, Jianghui Zhou¹, Yun Chang¹

¹Department of Heart Center, Tianjin Third Central Hospital, Tianjin University Central Hospital, The Third Central Clinical College of Tianjin Medical University, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Nankai University Affiliated Third Center Hospital; Medical college of Tianjin university, Tianjin ECMO Treatment and Training Base, Artificial Cell Engineering Technology Research Center, Institute of Hepatobiliary Disease, Tianjin, 300170, China. gaowq_1224@tju.edu.cn.

Journal of materials chemistry. B

|January 30, 2026

概括

这项研究开发了一种新的药物输送系统,使用巨细胞来减少动脉样硬化中的泡细胞形成. 该系统有效降低脂质积累,抑制斑块的形成,提供了一个有前途的新疗法策略.

科学领域:

生物医学工程生物医学工程
免疫学免疫学免疫学
心血管研究研究心血管研究

背景情况:

动脉样硬化治疗缺乏针对泡细胞形成的有效策略.
充满脂质的泡细胞是动脉样硬化斑块发展的核心.
目前的疗法在解决泡细胞积累的复杂机制方面存在局限性.

研究的目的:

设计一个巨纳米粒子复合药物输送系统用于动脉样硬化治疗.
为了利用巨细胞进行竞争性脂质吸收,并提供他类药物来抑制胆固醇合成.
开发针对性动脉样硬化治疗的"智能免疫调节"方法.

主要方法:

设计了一个巨纳米粒子复合药物输送系统.
利用巨细胞进行竞争性脂质吸收和对ROS敏感的他类纳米颗粒.
在动脉样硬化的APOE淘汰赛小鼠模型中评估了该系统.

主要成果:

通过抑制吸收和促进排泄,显著减少泡细胞中的脂质积累.
升级了ABCA-1和SR-BI表达,优化了微环境.
降低脂质水平,调节炎症,并减少动脉样硬化斑块的发育 in vivo.
增强调控T (Treg) 细胞增殖和TGF-β分泌.
已证明生物相容性,并训练了巨细胞恢复到低脂M2表型.

结论:

开发的系统为动脉样硬化提供了多目标治疗策略.
它集成了抑制胆固醇吸收,增强排泄和免疫调节.
这种方法显示出作为动脉样硬化的新治疗方法的显著前景.

更多相关视频

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms

Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms

Published on: April 11, 2017

相关概念视频

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

Atherosclerosis I: Introduction

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

What is Genetic Engineering?

What is Genetic Engineering?

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...

Atherosclerosis IV: Nursing Management

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...

Reversible and Irreversible Processes

Reversible and Irreversible Processes

The thermodynamic processes can be classified into reversible and irreversible processes. The processes that can be restored to their initial state are called reversible processes. It is only possible if the process is in quasi-static equilibrium, i.e., it takes place in infinitesimally small steps, and the system remains at equilibrium However, these are ideal processes and do not occur naturally. An ideal system undergoing a reversible process is always in thermodynamic equilibrium within...