微RNA-微生物群跨王国网络通过动态调节生态系统驱动炎症性肠病 (综述)
Liping Liang1, Xiaoyan Liu2, Bang Li3
1Department of Gastroenterology and Hepatology, Guangzhou Key Laboratory of Digestive Diseases, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, P.R. China.
International journal of molecular medicine
|January 30, 2026
概括
微RNAs (miRNAs) 在炎症性肠病 (IBD) 中调解肠道微生物群和宿主免疫之间的通信. 针对这些复杂网络的综合战略对于有效的IBD管理和精准医学至关重要.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 炎症性肠病 (IBD) 的发病包括复杂的宿主免疫和肠道微生物群相互作用.
- 微RNAs (miRNAs) 是宿主和肠道微生物之间的跨王国通信的关键媒介.
- 在IBD中失调的miRNAs破坏免疫平衡,影响炎症,淋巴细胞分化和上皮屏障功能.
研究的目的:
- 探索miRNAs在IBD病变发生中的作用及其与肠道微生物群的双向通信.
- 突出基于miRNA的治疗方法和IBD生物标志物的挑战和潜力.
- 倡导综合治疗策略,解决IBD中miRNA-微生物群相互作用的复杂性.
主要方法:
- 综述和综合目前关于IBD中miRNA功能的研究.
- 分析宿主衍生的miRNAs对细菌基因表达和微生物群落的影响.
- 研究肠道微生物群如何通过代谢物和免疫信号影响宿主miRNA的表达.
主要成果:
- 主体miRNAs调节细菌基因表达和微生物组成.
- 肠道微生物群通过代谢物和免疫路径影响宿主miRNA的表达.
- 失调的miRNAs有助于IBD的免疫失调和屏障缺陷,但通常表现出双重功能,使向治疗复杂化.
结论:
- 单一向的miRNA疗法由于网络弹性和补偿机制,其有效性有限.
- 有效的IBD管理需要综合战略,解决多个监管节点,而不是孤立的途径.
- 未来的研究应该专注于时间动态,空间组织和网络相互作用,用于IBD的精密医学方法.
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