牛津和身体活动在预防中风后认知衰退:一个多中心,随机对照试验
Jae-Sung Lim1, Joung-Ho Rha2, Jong-Ho Park3,4
1Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
European stroke journal
|January 30, 2026
概括
在高风险患者中,牛津并没有预防中风后的认知障碍. 这个研究研究这个研究.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 临床试验 临床试验
背景情况:
- 脑卒中后认知障碍 (PSCI) 影响了许多患者,影响了他们的生活质量.
- 牛津已被研究用于认知增强,但其在预防PSCI的有效性尚不清楚.
- 了解身体活动在PSCI中的作用和潜在的药物相互作用至关重要.
研究的目的:
- 评估牛津在预防中风后认知障碍 (PSCI) 的有效性.
- 为了探索oxiracetam和身体活动在PSCI预防中的相互作用.
- 用标准化测试和神经成像来评估认知功能的变化.
主要方法:
- 一个多中心,双盲,安慰剂对照试验,涉及500名高风险PSCI患者.
- 参与者接受了牛津或安慰剂36周.
- 使用MMSE和CDR-SB评估认知功能;通过动图监测身体活动;使用神经影像.
主要成果:
- 在牛津和安慰剂组之间,在MMSE或CDR-SB得分上没有发现统计学上显著的差异.
- 没有观察到oxiracetam和体育活动之间的相互作用.
- 探索性分析表明,对于高度活跃的氧化参与者来说,功能分离和CDR-SB具有潜在的益处.
结论:
- 在研究的高风险人群中,oxiracetam在预防PSCI方面没有显著的益处.
- 这些发现与韩国暂停使用oxiracetam的监管决定一致.
- 进一步的研究可能会探索特定的子组或组合干预.
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