开发一种基于血液的脂质体脂肪质量评分,用于测量缺血性中风风险
Iolanda Lázaro1,2,3, Leila Luján-Barroso4, Natalia Soldevila-Domenech1
1Hospital del Mar Medical Research Institute, Barcelona, Spain.
European stroke journal
|January 30, 2026
概括
基于红细胞脂肪酸的新脂质体脂肪质量 (LFQ) 评分,表明饮食脂肪质量. 较低的LFQ得分与较高的缺血性中风风险有关,这突显了饮食在预防中风方面的重要性.
科学领域:
- 营养流行病学 营养流行病学
- 心血管疾病生物标志物 心血管疾病生物标志物
- 利皮多米克 (Lipidomics) 是一种消化剂.
背景情况:
- 糟糕的饮食习惯是缺血性中风的重要危险因素.
- 红细胞脂肪酸 (RBC-FA) 作为长期饮食摄入的可靠生物标志物.
- 通过客观生物标志物评估饮食脂肪质量,对于了解中风风险至关重要.
研究的目的:
- 开发和验证基于血液的脂质体脂肪质量 (LFQ) 评分,使用RBC-FA.
- 调查LFQ得分与缺血性中风风险之间的关联.
- 为了确定饮食脂肪质量,按LFQ得分测量,是否会影响中风风险.
主要方法:
- 在EPIC-西班牙队列中进行了嵌入的病例控制研究.
- 在438例缺血性中风病例和438例匹配对照中分析了红细胞-FA.
- 根据对照中位数相对有利和有害的RBC-FA指标计算了8个组成部分的LFQ得分.
主要成果:
- 每增加1个单位的LFQ得分与缺血性中风的赔率比率 (OR) 降低0.86 (95%CI:0.770.95).
- 在LFQ得分最高的类别 (5-8分) 的个人与最低的类别 (0-3分) 相比,缺血性中风的几率明显较低 (OR = 0.64;95% CI:0.440.94).
- 这些发现在Framingham后代研究中得到了验证,显示中风风险比率 (HR) 降低,LFQ得分更高 (HR每单位增加=0.83;95%CI:0.700.99).
结论:
- 血基LFQ得分较低与缺血性中风风险增加有关.
- 来自RBC-FA的LFQ得分,是饮食脂肪质量及其对中风风险的影响的有价值指标.
- 这些发现强调了使用RBC-FA资料来评估中风风险和指导饮食建议的潜力.
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