索拉费尼布在患有晚期癌症的狗中临床有效性和耐受性
Doyun Kim1,2, Taekun Kim1, Youngsun Kim1
1BON Animal Medical Center, Suwon, Republic of Korea.
Veterinary and comparative oncology
|January 30, 2026
概括
索拉费尼布是一种多酶抑制剂,在患有晚期癌症的狗中显示出临床益处. 体重增加与积极反应有关,可能表明更好的预后.
科学领域:
- 兽医瘤学 兽医瘤学
- 药理学 药理学是指药理学的学科.
- 狗癌症治疗方法 狗癌症治疗方法
背景情况:
- 狗的晚期癌症具有有限的治疗选择和不良的预后.
- 多酶抑制剂索拉费尼布在临床前表现有前途,但在兽医中缺乏临床数据.
研究的目的:
- 评估口服索拉费尼布在患有晚期癌症的狗中的耐受性和临床疗效.
- 为了确定索拉费尼布治疗反应的潜在预后生物标志物.
主要方法:
- 对24只患有晚期癌症的狗进行了前性,开放式的队列研究.
- 口服索拉芬尼布 (6毫克/公斤每天一次),瘤反应通过RECIST标准评估,不良事件通过VCOG-CTCAEv2.0.0.
主要成果:
- 观察到总体临床益处率为58.3%.
- 病情进展的中位时间为51天,平均整体存活时间为65天.
- 患有的狗的存活时间明显更长;体重增加与临床益处有关.
结论:
- 索拉费尼布耐受性良好,为患有晚期癌症的狗提供可衡量的临床益处.
- 和体重增加可以作为治疗反应的预后指标.
- 在兽医瘤学中,需要对索拉费尼布和其他氨酸激酶抑制剂进行进一步的研究.
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