全球胰腺癌病例的急剧增长是由人口老龄化和可修改的风险驱动的
Wanyi Zheng1, Guojia Jiang1, Jolaoluwa Grace Oparinde1
1Shanghai University of Traditional Chinese Medicine, School of Public Health, Shanghai, China.
Journal of global health
|January 30, 2026
概括
胰腺癌 (PC) 是一种致命的疾病,其全球负担日益增加,特别是在老年人群中. 吸烟和高胆固醇等生活方式因素与PC有显著的相关性,需要有针对性的预防策略.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 胰腺癌 (PC) 是一种高度致命的恶性瘤,通常是晚诊断的.
- 治疗选择有限,导致预后不佳.
- 了解PC流行病学和风险因素对于全球卫生战略至关重要.
研究的目的:
- 在全球范围内描述当前的胰腺癌 (PC) 流行病学概况.
- 为了确定与生活方式相关的PC的贡献者.
- 预测未来PC的全球疾病负担.
主要方法:
- 利用2022年全球癌症观测中心 (GCO) 的发病率,死亡率和流行率数据.
- 从全球卫生观察站提取可修改的风险因素.
- 通过估计的年度百分比变化 (EAPC) 和预计的未来病例/死亡 (2022-2050年) 来评估时间趋势.
主要成果:
- 北美和欧洲的PC负担最高,男性比女性更容易受到影响.
- 在老年女性中,PC死亡率的增加令人担忧.
- 预测显示,到2050年,老年PC病例将增加85-91%,亚洲面临的病例数量最高,非洲死亡率增长最快.
- PC 的患病率与人体肥胖指数,胆固醇,吸烟和酒精消费有很强的相关性.
结论:
- 对于高负担地区 (北美,欧洲) 和高风险人口 (亚洲,非洲) 需要紧急的,特定区域的干预措施.
- 预计老年PC病例的增加和年轻女性出现的风险需要对可修改因素和适合性别的预防进行研究.
- 全球行动和以人口为目标的公共卫生措施对于减轻不断升级的PC负担至关重要.
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