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Updated: Jan 31, 2026
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在腹腔大动脉动脉瘤中识别了一种病态的前循环,该循环连接着酸盐,HIF1α信号和血管重塑
S Griepke1, G L Tripodi1, K L Kristensen2,3
1Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
European journal of clinical investigation
|January 30, 2026
概括
高酸盐水平与腹腔大动脉动脉瘤 (AAA) 的发展有关. 这项研究揭示了一种涉及HIF1α和血管光滑肌肉细胞变化的酸盐驱动途径,这表明AAA.的新治疗标.
科学领域:
- 代谢学 代谢学 代谢学
- 血管生物学 血管生物学
- 大动脉动脉瘤的发病原因
背景情况:
- 酸盐是参与代谢调节和细胞信号传递的关键代谢物.
- 腹腔大动脉动脉瘤 (AAA) 是一种危及生命的疾病,其特点是大动脉壁重塑.
- 苏酸在AAA病变发生过程中的确切作用尚不清楚.
研究的目的:
- 调查酸盐在腹腔大动脉动脉瘤 (AAA) 的发展和进展中的作用.
- 为了确定连接酸盐与AAA病变的分子机制.
- 探索苏酸盐-HIF1α轴作为AAA的潜在治疗点.
主要方法:
- 对来自AAA患者和对照组的人类血和大动脉组织样本的分析.
- 使用血管光滑肌细胞 (VSMC) 进行细胞培养实验.
- 公开AAA数据集的转录分析.
- 经心血管风险因素调整后的物流回归分析.
主要成果:
- 与对照组相比,AAA患者的血糖酸盐水平显著增加 (28%的增加) 显著增加.
- 在AAA大动脉组织中证实了酸盐的升高水平.
- 在AAA中酸盐的积累可能涉及酸盐脱酶的下调和VSMC中的玛-氨基黄油酸分流通路的上调.
- 在体外,VSMC脱差增加了酸盐的产生,而酸盐通过HIF1α信号促进了VSMC脱差.
结论:
- 苏酸盐通过一个积极的反循环作为AAA的驱动器,涉及HIF1α信号和VSMC表型切换.
- 已识别的酸盐-HIF1α轴代表了破坏AAA病理学的有前途的治疗标.
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