在患有先天性心脏病的成年人中,心力衰竭与保存的射出分数
Vanilla Maegaard Eriksen1, Chee Woon Lim1, Jani Thuraiaiyah1
1Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Inge Lehmanns Vej 7, Copenhagen 2100, Denmark.
European heart journal
|January 30, 2026
概括
心脏衰竭与保存的喷射分数 (HFpEF) 在先天性心脏病 (ACHD) 的成年人中很常见,影响13%的患者. 这些人面临着更高的并发病和住院的风险,但很少有人接受指南推的治疗.
科学领域:
- 心脏病学 心脏病学
- 成人的先天性心脏病 (ACHD)
- 心脏衰竭研究研究
背景情况:
- 在一般人群中,心力衰竭与保存的喷射分数 (HFpEF) 越来越普遍.
- 在患有先天性心脏病 (ACHD) 的成年人中,HFpEF的患病率和特征仍未得到充分研究.
研究的目的:
- 为了确定ACHD患者中HFpEF的患病率.
- 在这个人群中描述HFpEF,包括相关的并发症和住院率.
- 评估ACHD患者的HFpEF目前的治疗情况.
主要方法:
- 一项追溯的多中心队列研究,对4507名有双心室心脏生理和系统左心室的ACHD患者进行.
- 由保存的左心室喷射分数 (LVEF ≥50%) 定义的HFpEF,利尿剂的使用,以及升高的N-终端亲B型利尿素和/或心声学标志.
- 从电子病历中提取的数据.
主要成果:
- 86%的ACHD患者保持了LVEF;13%满足了HFpEF的标准,无论ACHD的严重程度如何.
- 高高血压患者年龄较大,患有更多的并发症 (糖尿病,肥胖,心房动),心血管住院率近五倍.
- 只有4.0%的人被正式诊断为心力衰竭,5.8%的人接受SGLT2抑制剂治疗.
结论:
- 在ACHD人群中,HFpEF非常普遍,与显著的并发症和住院负担有关.
- 目前在ACHD患者中对HFpEF的诊断和治疗率很低,特别是在SGLT2抑制剂方面.
- 提高对HFpEF的认识和主动管理对于改善ACHD患者的治疗结果至关重要.
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