长期动脉静脉的光神经MRI信号变化:与乳头和视觉衰退的相关性
Adarsh Anil Kumar1, Santhosh Kumar Kannath1, Jayadevan Enakshy Rajan1
1Neurointervention Center, Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
Journal of magnetic resonance imaging : JMRI
|January 30, 2026
概括
3D FLAIR MRI可以识别长期动脉静脉 (DAVF) 患者的视神经变化. 视神经中信号强度比 (SIR) 的升高与乳头发疹和视力下降相关,有助于诊断.
科学领域:
- 神经成像是一种神经成像.
- 眼科医生 眼科 眼科
- 血管神经学 血管神经学
背景情况:
- 持续性动脉静脉 (DAVF) 可能导致由于静脉高血压和内压力增加而导致视力下降,影响视神经轴质流动.
- 目前,对DAVF患者视神经参与的客观成像生物标志物有限.
研究的目的:
- 调查3D流体减弱反转恢复 (FLAIR) 光神经信号强度比 (SIR) 与DAVF患者的乳头或视力恶化之间的关联.
- 建立3D FLAIR MRI作为一个潜在的客观成像生物标志物,用于DAVF的视神经评估.
主要方法:
- 一项追溯观察性研究涉及54名数字减去血管造影 (DSA) 证实了DAVF患者和27名匹配的对照.
- 在3.0 T的3D FLAIRMRI被用于评估三位失明的神经放射学家的细分光神经信号强度比 (SIR).
- 主要结局包括 papilledema 状态和视力敏度;次要结局涉及视神经过强度和视力反应后栓塞.
主要成果:
- 与其他组相比,视力下降的DAVF患者的视觉神经SIR显著更高.
- 血管内部分的参与率最高 (51.8%).
- 一个1.7的SIR切线表明了皮皮和视力损失 (AUC=0.725) 之间的关联,视力恶化的敏感度为79.2%,特异性为63.3%.
结论:
- 3D FLAIR MRI可以检测DAVF患者的视神经信号异常.
- 在3D FLAIRMRI上增加的内眼神经SIR与DAVF患者的乳头膜炎和视力下降的存在相关.
- 这种技术显示出作为一个客观的成像生物标志物在DAVF中的视神经参与的承诺.
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