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信息处理速度对多发性硬化症视空间记忆编码和检索的影响
Pauline T Waskowiak1, Suzanne R de Jong1, Maureen van Dam2,3,4
1Medical Psychology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Journal of clinical and experimental neuropsychology
|January 30, 2026
概括
多发性硬化症 (PwMS) 患者的信息处理速度 (IPS) 损伤会对视觉空间记忆产生负面影响,尤其是在晚期学习和积极检索阶段. 这强调了在评估MS认知功能时需要考虑IPS的必要性.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 神经学 神经学
背景情况:
- 在患有多发性硬化症 (PwMS) 的人群中,信息处理速度 (IPS) 通常会受到损害,可能会影响其他认知功能.
- 虽然IPS和视觉空间记忆之间存在联系,但其对视觉空间记忆的不同组件的具体影响在PwMS中尚未完全理解.
研究的目的:
- 研究受损IPS与PwMS视觉空间记忆的编码,主动检索,被动检索和学习指数之间的关联.
- 为了确定IPS损伤是否预测特定视觉空间记忆子进程的性能缺陷.
主要方法:
- 追溯分析92个PwMS和29个健康对照 (HC) 的横截面数据.
- 使用符号数字模式测试 (SDMT) 来评估IPS.
- 使用简要的视觉空间记忆测试 - 修订 (BVMT-R) 评估视觉空间记忆;等级回归分析了IPS损伤的预测值 (z-score ≤-1.5).
主要成果:
- 近一半 (47.8%) 的PwMS显示SDMT减弱.
- IPS损伤显著预测后期学习试验 (第二和第三),主动检索和PwMS中BVMT-R的学习指数的表现较差.
- 对于初始学习,PwMS中的被动检索或HC中的任何BVMT-R组件,没有发现显著的关联.
结论:
- 具有IPS缺陷的PwMS显示视觉空间学习和记忆减少,特别是在高级编码阶段和主动信息回忆中.
- 这些发现强调了在多发性硬化症的背景下评估视觉空间记忆性能时考虑IPS状态的重要性.
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