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Updated: Jan 31, 2026

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中性细胞外细胞陷在儿科感染:一个系统的审查
Anastasia Stoimeni1, Nikolaos Gkiourtzis1, Vera Karatisidou1
14th Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 56403 Thessaloniki, Greece.
Current issues in molecular biology
|January 30, 2026
概括
中性粒细胞外细胞陷 (NETs) 在儿科感染中发挥作用,特别是呼吸系统疾病和发烧性尿路感染. 需要进一步的研究来标准化NET检测,并了解它们在儿童的预后价值.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 中性细胞外细胞陷 (NETs) 对于天生的免疫非常重要.
- 它们在儿科感染中的作用尚未完全理解,与成人疾病不同.
研究的目的:
- 系统地审查当前关于儿科感染中NET形成的证据.
- 识别知识缺口并指导该领域的未来研究.
主要方法:
- 按照柯克兰手册和PRISMA指南进行系统审查.
- 在 MEDLINE/PubMed 和 Scopus 数据库中进行了搜索.
- 使用修改后的纽卡斯尔-太华尺度评估研究质量.
主要成果:
- 包括11项研究.
- 在呼吸道感染中,NET与严重程度相关.
- 在发烧性尿路感染和严重的COVID-19 (MIS-C) 中发现了升高的NET标志物.
- 报道了有关败血症的不一致的发现.
结论:
- NETs与各种儿科感染有关.
- 建议对NET检测方法进行标准化.
- 需要进一步的研究来评估儿童的预后价值和机制.
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