皮肤功能载体降低LL-37和MMP的调节,并提高IGFBP-3的调节
Hudson Polonini1, Fabiana Regina da Silva Olímpio2, Carlos Rocha Oliveira2,3
1Fagron BV, Fascinatio Boulevard 350, 3065 WB Rotterdam, The Netherlands.
Current issues in molecular biology
|January 30, 2026
概括
克利奥德尔姆TM是一种新的护肤基,在皮肤共同培养模型中表现出显著的抗炎和矩阵保护作用. 它有助于调节免疫反应并保护皮肤结构,显示了和粉红管理的潜力.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 功能性皮肤基础可以积极调节皮肤平衡.
- 克利奥德尔姆TM是一种皮肤功能基础,具有抗炎,抗氧化和屏障支持的特性,具有专利的*Cleome gynandra*提取物,棕三酸-8,比萨博醇,酸和功能性油.
研究的目的:
- 在皮肤共同培养模型中评估CleodermTM的免疫调节和矩阵保护作用.
- 为了确定关键的生物标志物通过CleodermTM调节与和相关.
主要方法:
- 使用了人类角质细胞和纤维细胞共同培养模型.
- 克莱奥德尔姆TM在非细胞毒性度 (1.0%和10.0%) 测试时与或没有LPS刺激.
- 使用ELISA和RT-qPCR量化了细胞因子和矩阵金属蛋白酶 (MMP) 水平,而LL-37,IGFBP-3和TGF-β的蛋白质水平则通过Western blot进行了评估.
主要成果:
- 克莱奥德姆TM没有表现出高达10%的细胞毒性.
- 它显著降低了促炎媒介 (IL-6,TNF-α) 和MMP (MMP-1, -3, -13),同时增加了抗炎细胞因子 (IL-10,TGF-β).
- 克利奥德尔姆TM调节了LL-37和IGFBP-3水平,这表明对脂质脂肪生成和免疫调节的潜在益处.
结论:
- 克莱奥德姆TM作为一种活跃的皮肤功能基,缓解炎症并保持细胞外基质的完整性.
- 它调节关键的生物标志物 (LL-37,IGFBP-3) 相关的和疹.
- 这些发现支持使用CleodermTM作为个性化护肤的生物支持基础,并保证临床评估.
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