植物衍生剂和系统性硬化症:治疗潜力和分子机制的系统性审查
Cristian-Mihai Ilie1,2, Teodora-Cristiana Grădinaru1, Cătălina Anamaria Boromiz2
1Department of Functional Sciences I/Biochemistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Current issues in molecular biology
|January 30, 2026
概括
这篇评论探讨了系统性硬化症 (SSc) 的天然化合物,这是一种罕见的自身免疫性疾病. 有希望的植物衍生化合物显示出调节SSc通路的潜力,但需要更多的研究.
科学领域:
- 自身免疫性疾病是一种自身免疫性疾病.
- 药理学 药理学是指药理学的学科.
- 自然产品化学 自然产品化学
背景情况:
- 系统性硬化症 (SSc) 是一种罕见的,严重的自身免疫性疾病,其特征是纤维化,血管病变和免疫失调.
- 目前对SSc的治疗选择有限,这凸显了对新型治疗策略的需求.
- 植物化合物和药用植物是SSc.新的治疗剂的潜在来源.
研究的目的:
- 系统地审查和识别具有在全身性硬化症中被证明有效性的植物化合物和药用植物.
- 探索这些与SSc病变发生相关的自然化合物的潜在分子标.
主要方法:
- 在PubMed和ScienceDirect进行了系统的文献搜索.
- 使用SwissTargetPrediction工具来识别潜在的分子目标.
- 通过文献搜索,确定目标与SSc病原体的相关性得到验证.
主要成果:
- 该审查确定了24种植物化合物和5种植物提取物,这些植物提取物对SSc.有潜在的益处.
- 这些化合物被发现调节关键的致病过程,包括内皮-介质细胞过渡,氧化应激,炎症和TGF-β/Smad信号传递.
- 确定了93个新的潜在分子标,其中41个与SSc.相关.
结论:
- 有证据表明,某些植物化合物和植物提取物在调节SSc病变发生方面表现有前途.
- 已识别的天然化合物准了参与纤维化,炎症和血管功能障碍的关键途径.
- 进一步的临床研究,特别是人体试验,对于确定这些天然剂在SSc管理中的有效性和安全性至关重要.
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