长链脂肪酸可以抑制髓状细胞的抑制细胞,延迟瘤的进展
Xinyu Liu1, Fanni Kong1, Zhangyuzi Deng1
1State Key Laboratory of Membrane Biology, School of Life Sciences, IDG/McGovern Institute for Brain Research, Center for Life Sciences, Peking University Third Hospital Cancer Center, Peking University, Beijing 100871, China.
Current issues in molecular biology
|January 30, 2026
概括
长链脂肪酸 (LCFA) 直接影响髓质衍生抑制细胞 (MDSC),减少免疫抑制和延迟瘤进展. 这一发现揭示了LCFAs作为一种新的治疗点,用于增强癌症治疗中的抗瘤免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢途径 代谢途径
- 癌症生物学 癌症生物学
背景情况:
- 瘤的进展受宿主代谢的影响.
- 瘤免疫微环境中代谢调节的机制尚未完全理解.
- 骨髓系衍生抑制细胞 (MDSCs) 是瘤免疫微环境的关键调节者.
研究的目的:
- 调查长链脂肪酸 (LCFA) 在调节髓质衍生抑制细胞 (MDSCs) 中的作用.
- 探索LCFA对瘤免疫微环境和癌症进展的影响.
主要方法:
- 在体外和体内实验中,MDSC暴露于LCFA.
- 在单细胞MDSCs (M-MDSCs) 和多态核核MDSCs (PMN-MDSCs) 中免疫抑制基因表达的分析.
- 在食高LCFA饮食的小鼠中评估瘤进展和生存,包括对裸体小鼠的实验.
主要成果:
- 在M-MDSC和PMN-MDSC中,LCFA暴露显著降低了免疫抑制基因表达.
- 吃高LCFA饮食的小鼠在各种癌症模型中表现出延迟瘤进展和延长生存时间.
- LCFA诱导的MDSC抑制与增强的CD8+T细胞抗瘤免疫相关,这种效应在裸体小鼠中不存在.
结论:
- 长链脂肪酸 (LCFA) 直接调节MDSC功能,降低它们的免疫抑制能力.
- 饮食中的LCFA可以通过向MDSCs来抑制瘤进展并增强抗瘤免疫力.
- 通过影响瘤免疫微环境,LCFA代表了癌症治疗的新治疗途径.
相关概念视频
02:07Tumor Progression
7.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.4K
01:12Loss of Tumor Suppressor Gene Functions
6.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.1K
01:28Overview of Fatty Acid Metabolism
36.9K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
36.9K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
9.8K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.8K
01:25Acidity and Basicity of Carboxylic Acid Derivatives
4.4K
Carboxylic acids are the strongest among organic acids, as they readily lose the hydroxyl proton to form a resonance-stabilized carboxylate ion. In comparison, the acid derivatives lack acidic hydrogens directly attached to a functional group. In these compounds, the acidic nature arises from their ability to lose α hydrogens, making them weakly acidic.
The relative acidic strength of the derivatives can be explained based on the extent of resonance stabilization of the conjugate base. The...
The relative acidic strength of the derivatives can be explained based on the extent of resonance stabilization of the conjugate base. The...
4.4K
01:28Electron Transport Chains
112.1K
The final stage of cellular respiration is oxidative phosphorylation that consists of two steps: the electron transport chain and chemiosmosis. The electron transport chain is a set of proteins found in the inner mitochondrial membrane in eukaryotic cells. Its primary function is to establish a proton gradient that can be used during chemiosmosis to produce ATP and generate electron carriers, such as NAD+ and FAD, that are used in glycolysis and the citric acid cycle.
The ETC is comprised of...
The ETC is comprised of...
112.1K