荷兰的空中真菌在很大程度上反映了荷兰的临床隔离物导致真菌菌病
Mandy de Jong1, Hylke Kortenbosch2, Eveline Snelders2
1Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Medical mycology
|January 30, 2026
概括
这项研究优化了空气样本中Mucorales真菌的培养,在荷兰空气和患者感染中发现了像Rhizopus microsporus这样的常见物种. 这表明了空气传播的真菌和粘菌菌之间的联系.
科学领域:
- 环境微生物学环境微生物学
- 医学真菌学 医学真菌学
- 菌是通过空气传播的病原体.
背景情况:
- 藻类物种是已知的人类病原体,引起菌菌病.
- 感染的主要途径通常被认为是吸入,但直接证据将空气传播物种与临床隔离物种联系起来是有限的.
- 了解空气中的真菌菌的多样性对于评估公共卫生风险至关重要.
研究的目的:
- 确定从空气样本中培养Mucorales物种的最佳方法.
- 为了研究荷兰环境空气中存在的Mucorales物种的多样性.
- 为了比较空气传播的Mucorales物种与在人类粘菌菌感染中发现的物种.
主要方法:
- 优化培养方案使用Sabouraud乳酸,沃里科纳和30°C的化.
- 采集和分析了荷兰各地120个空气样本,使用三角洲陷空气采样方法.
- 使用形态学,MALDI-TOF MS,显微镜和ITS PCR,与17个临床隔离物进行比较,在属和物种层面确定了粘菌.
主要成果:
- 优化的方法成功地从空气中培养出各种各样的Mucorales物种.
- 鉴定到的空气传播物种包括Rhizomucor pusillus,Rhizopus microsporus和Mucor circinelloides. 这些物种被认为是空气传播物种.
- 临床粘膜菌病例中也经常发现Rhizopus microsporus和Mucor circinelloides;10种空气传播物种中有3种与临床隔离物相匹配.
结论:
- 建立了一种选择性和有效的方法来培养空气传播的真菌菌.
- 在环境空气中发现的Mucorales物种和在荷兰引起人类感染的物种之间存在显著的重叠.
- 这项研究提供了第一个直接证据,支持空气传播和临床相关的Mucorales物种的相似性,加强了吸入性粘膜菌病的吸入假设.
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