高脂肪和缺乏胆的西方饮食破坏了小鼠†的卵巢微环境
César A Pinzón-Osorio1, Camila L Moreira2, Ines L Assis2
1College of Veterinary Medicine, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
Biology of reproduction
|January 30, 2026
概括
饮食诱导的代谢压力,从高脂肪或西方风格的饮食,重塑卵巢微环境,显示生殖衰老的早期迹象. 这种情况独立于卵泡枯竭,突出了代谢疾病和生殖能力下降之间的新联系.
科学领域:
- 生殖生物学 生殖生物学
- 代谢性疾病 代谢性疾病
- 卵巢老化 卵巢老化
背景情况:
- 由于饮食不良而导致的肥胖和代谢功能障碍有助于生殖衰老.
- 由于饮食引起的肥胖和肝损伤在卵巢衰老中的具体作用尚未完全理解.
研究的目的:
- 研究高脂肪饮食 (HFD) 和缺乏胆的西方饮食 (CDWD) 对两种小鼠株的卵巢衰老的影响.
- 为了确定饮食诱导的肥胖或肝损伤是否驱动卵巢衰老的特征.
主要方法:
- 雌性小鼠 (C57BL/6和瑞士) 接受了标准,胆缺乏,HFD或CDWD的10周的食.
- 评估的体重,脂肪积累,胰岛素抵抗,肝脏健康,血清脂质和卵巢微环境.
- 评估了卵巢卵泡储备和缩.
主要成果:
- 在C57BL/6小鼠中,HFD诱导肥胖和胰岛素抵抗,但不是瑞士小鼠.
- 在没有肥胖的两种菌株中,CDWD导致肝损伤 (肝壮病,脂肪肝炎).
- 这两种饮食都改变了血清脂质,并促进了卵巢 stromal 纤维化,巨细胞透,脂素积累和增加的 stromal 增殖,独立于卵泡枯竭.
结论:
- 来自HFD和CDWD的代谢压力重塑卵巢微环境,诱导早期的卵巢衰老迹象.
- 卵巢微环境的重塑是独立于卵泡枯竭的.
- 肥胖驱动的代谢功能障碍和不依赖肥胖的肝损伤都会导致卵巢衰老,揭示了一条将代谢健康与生殖衰老联系起来的途径.
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