精液微生物组与男性生殖健康之间的关系:一项系统性审查†
Baharan Bazzar1, Elmira Reshadfar1, Parham Namdar1
1Department of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Biology of reproduction
|January 30, 2026
概括
精子微生物组显著影响男性生育能力. 这些微生物的不平衡,即失生症,与不孕症和其他生殖健康问题有关.
科学领域:
- 生殖生物学和微生物学.
- 男人生殖健康 男人生殖健康
- 微生物组研究的研究.
背景情况:
- 男人生殖道曾经被认为是无菌的,但现在却是复杂微生物群的所在地.
- 这种精子微生物组影响精液质量和男性生育能力.
- 微生物失衡 (失生症) 与不孕症,炎症和前列腺疾病有关.
研究的目的:
- 系统地审查精液微生物群对男性生殖健康的影响.
- 确定关键的微生物参与者及其与生育和疾病的关联.
- 探索微生物组介导对精子参数的影响背后的机制.
主要方法:
- 按照PRISMA 2020指导方针进行系统审查 (2025年扩展).
- 在PubMed,Scopus和Science Direct数据库中进行了搜索 (2015-2025,有先前的上下文).
- 包括人体,体外和动物模型研究.
主要成果:
- 固菌菌,蛋白质菌,动菌菌和细菌菌群是主要的类型.
- 有益的属 (例如,乳杆菌) 增强了精子参数;异生物种类 (例如,Prevotella,Pseudomonas) 是有害的.
- 性活动会影响微生物转移和失生症;疾病特异性变化 (例如,HPV+中的Fusobacterium) 会加剧问题.
结论:
- 精子微生物组显著改变精子功能,并导致不孕.
- 需要进一步的标准化,长期研究来确定因果关系.
- 益生菌和其他干预措施显示出恢复微生物平衡和改善生育能力的潜力.
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