长期不匹配的负面性延迟在重症监护病房患有活跃狂妄症的病人
Yi-Cian Chen1,2,3, Huai-Jen Chang4, Ching-Wen Chang1
1Department of Occupational Therapy, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan.
概括
患有功能障碍的重症患者经历妄,显示长期不匹配负面 (MMN) 的大脑活动. 这种电生理学标记表明,在ICU的活跃狂妄发作期间,神经处理发生了改变.
科学领域:
- 神经科学是一个神经科学.
- 临界护理医学 临界护理医学
- 电子生理学 电子生理学
背景情况:
- 狂妄症是重症患者常见和严重的并发症,与增加的死亡率和认知缺陷有关.
- 功能障碍是重症监护室 (ICU) Delirium 的已知危险因素.
- 了解活跃妄想发作的神经生理学至关重要,但尚未得到充分研究.
研究的目的:
- 研究功能障碍重症患者 Delirium 的神经生理特征.
- 为了利用不匹配负面性 (MMN) 作为一种电生理学标记,以研究在妄想期间的大脑活动.
- 探索MMN,痴呆症严重程度,认知功能和临床结果之间的关系.
主要方法:
- 听觉奇怪范式用于记录事件相关的潜力,并测量ICU患有功能障碍的ICU患者的MMN.
- 通过从标准音调中减去对偏差音调的反应来计算MMN.
- 在患有 Delirium 和没有 Delirium 的患者之间进行了 MMN 的比较,并评估了它与认知功能,疾病严重程度和临床结果的关联.
主要成果:
- 与没有妄想症的患者相比,患有妄想症的患者表现出显著延长的MMN延迟 (P = 0.005).
- 延迟的MMN延迟显示出与 delirium 严重程度增加相关的趋势.
- MMN没有预测ICU出院时的临床结果.
结论:
- 患有功能障碍的重症患者在妄想期间表现出长时间的MMN延迟.
- 这些发现表明,ICU患者经历 Delirium 的大脑中神经处理发生了变化.
- 在这种人群中,MMN可以作为一种有价值的标志物,以了解狂妄病理生理学.
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