使用实验设计方法开发和优化用于阴道药物输送的电聚乙烯醇纳米纤维
Sinem Saar1, Fatmanur Tuğcu-Demiröz1, Füsun Acartürk1
1Gazi University Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Türkiye.
Turkish journal of pharmaceutical sciences
|January 30, 2026
概括
聚乙醇纳米纤维被优化为阴道药物输送. R3配方 (7.5%PVA,乙醇/DW,1000rpm) 显示出优异的机械和粘粘性特性,可增强阴道给药.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 阴道纳米纤维为药物管理提供了一个有前途的平台,因为它具有很高的表面积和可调节的多孔性.
- 聚乙醇 (PVA) 是一种适用于制药应用的聚合物,具有水友性,生物降解性,无毒性和粘粘性特征.
研究的目的:
- 优化基于聚乙醇 (PVA) 的电纳米纤维用于阴道药物输送.
- 用实验设计方法评估聚合物度,溶剂系统和收集器旋转速度对纳米纤维特性的影响.
主要方法:
- 使用蒸水 (DW) 用N,N-二甲基形式胺 (DMF) 或乙醇制备PVA溶液.
- 电参数包括PVA度 (7.5%,15%),收集器旋转速度 (100,1000rpm) 和溶剂系统 (DMF:DW,乙醇:DW).
- 纳米纤维的机械和粘粘性性能使用纹理分析仪和ex vivo粘粘性研究进行了评估.
主要成果:
- 增加的PVA度提高了粘度,导电性和抗拉强度 (1.41±0.07到3.92±0.14MPa).
- 纳米纤维直径从196±41nm到1721±114nm不等,所有配方均显示完全可湿性 (0°接触角).
- R3配方 (7.5%PVA,乙醇/DW,1000rpm) 呈现出最高的粘粘度,受收集器旋转速度的影响.
结论:
- 溶剂系统和收集器旋转速度显著影响纳米纤维形态.
- 该R3配方表现出优异的机械和粘粘性,使其适用于阴道药物输送.
- 聚合器旋转速度,聚合物度和溶剂系统是定制PVA纳米纤维以提高机械和粘粘性能的关键因素.
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