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Updated: Jan 31, 2026

DNAzyme-dependent Analysis of rRNA 2’-O-Methylation
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DNAzyme-dependent Analysis of rRNA 2’-O-Methylation

Published on: September 16, 2019

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对23SrRNA甲基化酶Cfr的结构分析揭示了甲基化区域特异性和抗生素耐药性的RNA结合决定因素

Michael Fruci1,2, Annia Rodríguez Hernández3, Tatiana Skarina4

  • 1London Research and Development Centre, Agriculture and Agri-Food Canada, London, Ontario N5V 4T3, Canada.

ACS infectious diseases
|January 30, 2026
PubMed
概括

通过甲基化23S.rRNA,Cfr酶通过甲基化23S.rRNA赋予多药性耐药性. 这项研究揭示了Cfr酶结构,并确定了Q329等关键残留物,这些残留物对其甲基化活性和抗生素耐药性至关重要.

关键词:
阿尔法折叠是什么意思阿尔法折叠抗微生物耐药性 抗微生物耐药性结晶学 结晶学是指结晶学.质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量甲基转移酶的使用方法核糖体的核糖体是指核糖体中的核糖体.

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