开发和评估化表面修饰的氧酸纳米颗粒,用于增强膜透
Rajamma Abburu Jayaramu1,2, Sateesha Shivally Boregowda3, Shivanand K3
1Department of Pharmacognosy, KLE College of Pharmacy, Bengaluru, India.
Cutaneous and ocular toxicology
|January 30, 2026
概括
使用 cetyltrimethylammonium bromide 开发了带有正电荷的,含有metronidazole 的酸纳米颗粒,以提高皮肤透率和治疗效果. 这些新型纳米粒子显示了改善的膜相互作用和细胞兼容性,用于先进的药物输送.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 酸 (HP) 纳米粒子是具有药物输送潜力的生物相容材料.
- 调节纳米粒子表面电荷对于增强与生物膜相互作用至关重要.
- 甲尼达是一种关键的抗微生物药物,通常需要改进的输送系统.
研究的目的:
- 开发带有正电荷的甲化醇载荷的酸 (MZ-HP) 纳米粒子.
- 通过使用 cetyltrimethylammonium bromide (CT) 的表面电荷调制来增强膜相互作用,透和治疗疗效.
主要方法:
- 从蛋中提取的氧化中合成的半孔HP纳米颗粒,并加载了metronidazole.
- 通过物理吸收通过CT (1-3.5mM/g) 涂层的MZ-HP纳米粒子.
- 使用FTIR,XRD,SEM,TEM和动态光散射来表征纳米粒子;评估了ex vivo皮肤透和体外细胞相容性.
主要成果:
- 在药物与载体比为0.83M:1M的情况下,达到87.2%的最大甲尼达加载效率.
- 通过CT.成功地将表面电荷从负 (HP,MZ-HP) 逆转为正 (+21.9 ± 3.3 mV) 使用CT.
- 对于CT-MZ-HP,已经证明了透性流量的增加 (1.285至1.582毫克/小时·厘米2) 和纤维细胞耐受性的改善 (IC50 = 184.9 ± 3.12μg/毫升).
结论:
- 涂有CT涂层的MZ-HP纳米粒子代表了一个有效的电荷调制纳米载体系统.
- 这些纳米粒子表现出增强的跨屏障运输,膜相互作用和细胞内接入.
- 开发的系统显示了作为下一代抗微生物药物配送平台的潜力,具有改进的细胞相容性.
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