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漠不关心和抑郁对认知衰退的影响:神经退行性疾病中的神经心理特征
Serena Oliveri1,2, Francesca Gastaldo2, Natale Vincenzo Maiorana1
1Department of Health Sciences University of Milan, "Aldo Ravelli" Center for Neurotechnology and Brain Therapeutics, Via A. di Rudinì, 8-ASST Santi Paolo e Carlo-Corpo C, Milano, MI 20142, Italy.
概括
无动于衷是神经退行性疾病中常见的,如血管性痴呆和帕金森病,影响认知功能和日常生活. 这项研究区分了冷漠和抑郁对认知和自主性的影响.
科学领域:
- 神经心理学 神经心理学
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 漠不关心是神经退行性疾病中普遍存在的症状,但其起源和对认知和日常自主性的具体影响,特别是与抑郁症相伴,尚未完全理解.
- "血管冷漠假设"表明血管问题先于冷漠,而多巴胺通路功能障碍也与此有关.
- 了解冷漠与抑郁症的不同影响对于管理认知衰退和保持患者的独立性至关重要.
研究的目的:
- 在血管痴呆症,帕金森病 (PD) 和轻度认知障碍-阿尔茨海默病 (MCI-AD) 中对无动于衷的特征,涉及发病率,严重程度和认知特异性.
- 在这些患者群体中区分冷漠和抑郁对认知障碍和日常生活活动 (ADL) 的影响.
主要方法:
- 一项涉及53名被诊断患有血管痴呆症,PD或MCI-AD的患者的横截面研究.
- 参与者接受了神经心理测试,并完成了经过验证的抑郁症 (老年抑郁症量表),冷漠 (斯塔克斯坦的冷漠度表) 和功能自主性 (ADL问卷) 的量表.
主要成果:
- 漠不关心预测语言主动性,独立于抑郁症 (p=.028).
- 漠不关心与工作记忆,语言和前额功能有相反的相关性.
- 抑郁症预测自主,独立于冷漠 (p=.036).
- 在研究的神经退行性疾病中,无论是冷漠还是抑郁的患病率或严重程度都没有显著差异.
结论:
- 漠不关心是各种神经退行性疾病中常见且显著的症状,加剧了特定的认知缺陷.
- 虽然这项研究强调了冷漠对认知功能的影响和抑郁对自主性的影响,但将血管冷漠与其他形式区分开来仍然是一个临床挑战.
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