生活质量,自我报告的认知困难和多发性硬化症的基于表现的认知问题:睡眠与此有什么关系?
Kaitlin E Riegler1, Cristina A F Román2,3, Erin T Guty4
1RWJBarnabas Health Medical Group, Multiple Sclerosis Comprehensive Care Center, Livingston, NJ, USA.
概括
多发性硬化症 (PwMS) 患者的睡眠质量差与更多自我报告的认知问题和生活质量 (QoL) 降低有关,但不是客观的认知表现. 解决睡眠问题可能会改善PwMS的QoL.
科学领域:
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
- 康复医学 康复医学 康复医学
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经疾病,影响认知功能和生活质量 (QoL).
- 睡眠障碍在患有多发性硬化症 (PwMS) 的人群中很常见,可能会影响他们的日常功能.
- 在PwMS中睡眠质量,认知表现和QoL之间的关系需要进一步调查.
研究的目的:
- 为了比较PwMS与睡眠质量差与充足的睡眠质量之间的认知功能 (基于表现和自我报告).
- 评估睡眠质量对PwMS的QoL的影响.
- 为了确定睡眠质量是否预测MS中的QoL结果,控制相关因素.
主要方法:
- 一项涉及97个PwMS的横截面研究,分为睡眠质量差 (n=22) 和充足 (n=72) 的组.
- 用神经心理测试和自我报告措施来评估认知功能.
- 使用多发性硬化症功能评估 (FAMS) 评估生活质量 (QoL),通过睡眠习惯问卷测量睡眠质量.
主要成果:
- 在基于表现的认知功能中,在睡眠质量差和充足的睡眠质量组之间没有发现显著的差异.
- 与睡眠质量不佳的PwMS患者相比,睡眠质量不佳的PwMS患者报告认知困难的比例明显高 (86.36%与40.28%,p < .001).
- 在控制疾病进展,抑郁和疲劳后,睡眠质量差显著预测了症状QOL (R2=.04,p=.03) 和疲劳QOL (R2=.05,p=.02).
结论:
- 在PwMS中,睡眠质量差与自我报告的认知困难增加有关,而不是客观认知障碍.
- 睡眠质量是 QoL 的重要预测因素,特别影响 PwMS 中的症状感知和疲劳水平.
- 针对睡眠质量的干预措施可能有助于改善多发性硬化症患者的整体QOL.
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